SUPER TONGUE MAKES IT SWEETER
Say Goodbye to Bitter Medicines
Super Tongue is invaluable in pharmaceutical production, particularly for taste masking of Active Pharmaceutical Ingredients (APIs). APIs like paracetamol, ibuprofen, diclofenac, and caffeine, essential for treatments, often have bitter taste profiles that require effective taste masking.
Traditional methods involve coating tablets or capsules with inert materials. However, for pediatric and geriatric treatments where liquid formulations are necessary, taste masking becomes crucial. While sweeteners and artificial flavors are commonly used, evaluating the bitterness and effectiveness of taste-masking components is vital for quality control during drug formulation. Human testing panels introduce subjectivity and ethical concerns, and laboratory animals pose challenges in early drug development stages.
Super Tongue offers an ethical and efficient solution for taste determination. Established systems, such as Alpha MOS AstreeII and Intelligent Sensor Technology Inc.’s TS-5000Z, are used for API taste masking analysis.
Current research focuses on developing novel sensors to assess API taste masking strategies. For instance, a potentiometric sensor array can differentiate between APIs like Ibuprofen and Rixithromycin, revealing the impact of microencapsulation on taste masking for both compounds. Studies on the bitter taste of sodium caseinate hydrolysates and the use of sweeteners as masking agents provide valuable insights into taste-masking methodologies.
Collaborative efforts among electronic tongue specialists compare commercial systems with laboratory-developed sensor arrays. These studies, conducted under blind conditions, evaluated formulations with different masking agents. Results indicated similarities between arrays based on potentiometric sensors and distinctive clustering patterns in voltammetric systems. The advanced features of Super Tongue make it a valuable asset in refining API taste masking.
BIOMEDICAL RESEARCH
Get to Know Fluid Changes
Super Tongue excels in biomedical research, particularly in the analysis of biological fluids. Its technical adaptability and versatility make it a robust diagnostic tool for identifying and monitoring early stages of pathological processes associated with various diseases.
In biomedical investigations, Super Tongue effectively scrutinizes biological fluids such as urine, serum, blood, and sweat. In clinical urine analysis, it accurately distinguishes samples from healthy individuals and those with renal dysfunction, providing a valuable means for early disease detection. Numerous systems have been proposed for predicting the quantity of ions and specific compounds in urine, significantly contributing to clinical monitoring of kidney diseases and urinary tumors.
In blood analysis, Super Tongue enhances precision by eliminating interferents. A promising research avenue is the continuous monitoring of hemodialysis processes using implantable all-solid-state ion-selective electrodes, which prove effective for endoscopic studies and hemodialysis procedures.
Super Tongue technology also extends to sweat analysis, utilizing tattoo sensors strategically positioned on the body for real-time analysis of ions, glucose, lactic acid, and other components during perspiration. This wearable tattoo sensor enhances performance monitoring in athletes and detects metabolic disorders. Disposable screen-printed sensors quantifying chloride in sweat are particularly relevant for early detection of cystic fibrosis.