Super Tongue finds application in pharmaceutical production, particularly in taste masking strategies for Active Pharmaceuticals Ingredients (API).
APIs, such as paracetamol, ibuprofen, diclofenac, and caffeine, crucial for pharmaceutical treatment, often possess bitter taste profiles, necessitating effective taste masking techniques. Conventional methods involve coating tablets or capsules with inert materials, but in scenarios like pediatric and geriatric treatments, liquid formulations are imperative, intensifying the importance of taste masking. Common strategies employ sweeteners and artificial flavors, but the evaluation of bitterness and taste-masking components is pivotal for quality control during drug formulation.
Human testing panels introduce subjectivity and ethical concerns, while laboratory animals present challenges in early drug development. To address these issues, Super Tongue emerges as an ethical and efficient tool for taste determination. Commercial systems, such as Alpha MOS AstreeII and Intelligent Sensor Technology Inc.’s TS-5000Z, have been established for API taste masking analysis.
Current research focuses on the development of novel sensor types to assess API taste masking strategies. For instance, a potentiometric sensor array demonstrated discrimination between common APIs like Ibuprofen and Rixithromycin, revealing the comparable impact of microencapsulation on taste masking for both compounds. Investigations into the bitter taste of sodium caseinate hydrolysates and the utilization of sweeteners …
as masking agents contribute valuable insights into taste-masking methodologies.
Recent collaborative efforts among specialists in electronic tongues involved the comparison of commercially available systems with laboratory-developed sensor arrays. This study, conducted under blind conditions, evaluated nine formulations of different masking agents. Results indicated similarities between arrays based on potentiometric sensors and distinctive clustering patterns in voltammetric systems. The advanced features of Super Tongue position it as a valuable asset in the ongoing refinement of API taste masking.
Super Tongue shows excellent skills in biomedical research, specifically in the intricate analysis of biological fluids. With its technical adaptability and versatility, this system is a robust diagnostic tool for the identification and monitoring of early stages in pathological processes associated with diverse diseases.
In biomedical investigation, Super Tongue showcases efficacy in scrutinizing various biological fluids, spanning urine, serum, blood, and sweat. Notably, in the clinical analysis of urine, this instrument excels in accurately discerning samples from healthy individuals and those afflicted with renal dysfunction, offering a valuable means for early disease detection. Numerous systems have been proposed for predicting the quantity of ions and specific compounds in urine, contributing significantly to the clinical monitoring of kidney diseases and urinary tumors.
In blood analysis processes, Super Tongue proves advantageous due to its capability to eliminate interferents, thereby enhancing analysis precision. A promising avenue of research entails the continuous monitoring of hemodialysis processes, wherein the utilization of implantable all-solid-state ion-selective electrodes proves efficacy for distinguishing advancements in both endoscopic studies and hemodialysis procedures.
The application of Super Tongue technology extends to sweat analysis, leveraging tattoo sensors strategically positioned on the body for real-time analysis of ions, glucose, lactic acid, and other components during perspiration. This wearable tattoo-sensor holds promise for enhancing performance monitoring in athletes and detecting metabolic disorders. Disposable screen-printed sensors capable of quantifying chloride in sweat are particularly pertinent for the early detection of cystic fibrosis.